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Identification of an Oculomotor biomarker of Preclinical Huntington Disease
Neurol 67:485-487, Golding,C.V.P.,et al, 2006
See this aricle in Pubmed
Article Abstract
The authors examined oculomotor function to identify a biomarker of disease progression in genetically confirmed preclinical and early clinical Huntington disease (HD). Initiation deficits of voluntary-guided, but not reflexive, saccades were characteristic of preclinical HD. Saccadic slowing and delayed reflexive saccades were demonstrated in clinical but not preclinical HD. Saccadic measures provide biomarkers of disease progression in both preclinical and early clinical stages of HD.
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eye movement,disorders of
Huntington's chorea
Huntington's chorea,presymptomatic detection of
neurologic disease,diagnoses of
saccadic eye movements
saccadic eye movements,abnormal
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